DMD #19034 Subcellular distribution of inorganic and methylated arsenic compounds in human urothelial cells and human hepatocytes
نویسندگان
چکیده
Institute of Hygiene and Occupational Medicine, University Hospital Essen, University of Duisburg-Essen, Germany (E.D., U.v.R., I.S., I.P., A.W.R.), Institute of Environmental Analysis, University of Duisburg-Essen, Germany (L.M.H., S.R., A.V.H.), Chemical Research Department, Matís, Reykjavík, Iceland (S.R.), Department of Traumatology, TU Munich, Germany (L.H., A.N.), Department of Toxicology, University of Wageningen, The Netherlands (C.K.) DMD Fast Forward. Published on February 8, 2008 as doi:10.1124/dmd.107.019034
منابع مشابه
Subcellular distribution of inorganic and methylated arsenic compounds in human urothelial cells and human hepatocytes.
Epidemiological studies have indicated that exposure of humans to inorganic arsenic in drinking water is associated with the occurrence of bladder cancer. The mechanisms by which arsenic induces this malignancy are still uncertain; however, arsenic metabolites are suspected to play a pivotal role. The aim of the present study was the investigation of uptake capabilities of human urothelial cell...
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In humans, arsenic is primarily metabolized by arsenic (+3 oxidation state) methyltransferase (As3MT) to yield both trivalent and pentavalent methylated metabolites. We recently reported that the putative N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) can biotransform monomethylarsonous acid (MMA(III)) to dimethylarsinic acid, conferring resistance of human cells to arsenic exposure. To ...
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Thio-dimethylarsinic acid (thio-DMA(V)) has recently been identified as human metabolite after exposure toward both the human carcinogen inorganic arsenic and arsenosugars, which are the major arsenical constituents of marine algae. This study aims to get further insight in the toxic modes of action of thio-DMA(V) in cultured human urothelial cells. Among others effects of thio-DMA(V) on eight ...
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Inorganic arsenic (iAs) is a well-established carcinogen and human exposure has been associated with a variety of cancers including those of skin, lung, and bladder. High expression of transforming growth factor alpha (TGF-alpha) has associated with local relapses in early stages of urinary bladder cancer. iAs exposures are at least in part determined by the rate of formation and composition of...
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